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eBook The Genetics of Systemic Lupus Erythematosus: Mapping of Susceptibility Loci for Human Sle (Comprehensive Summaries of Uppsala Dissertations) download
Science
Author: Anna-Karin B. Lindqvist
ISBN: 9155445861
Subcategory: Evolution
Publisher Uppsala Universitet (November 1, 1999)
Language English
Category: Science
Rating: 4.3
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ePUB size: 1785 kb
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eBook The Genetics of Systemic Lupus Erythematosus: Mapping of Susceptibility Loci for Human Sle (Comprehensive Summaries of Uppsala Dissertations) download

by Anna-Karin B. Lindqvist


Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin . The locus was denoted hSLE1. To further evaluate the 2q37 region we analyzed additional microsatellite markers in families from Iceland; Sweden and Norway.

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. The highest two-point lod score was obtained for the marker D2S125 and the multipoint analysis indicated the position of the locus between D2S125 and D2S2986 with a peak lod score of . 9 at D2S125.

Goodreads helps you keep track of books you want to read. by Anna-Karin B. Lindqvist. Start by marking The Genetics of Systemic Lupus Erythematosus: Mapping of Susceptibility Loci for Human Sle as Want to Read: Want to Read savin. ant to Read.

Systemic lupus erythematosus (SLE) is a prototype systemic . 2000) A susceptibility locus for human systematic lupus erythematosus (hSLE1) on chromosome 2q. J. Autoimmun.

Systemic lupus erythematosus (SLE) is a prototype systemic, autoimmune inflammatory disease that can involve virtually any organ or tissue type.

Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease. Tsao BP: The genetics of human lupus. Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease. Genetic factors are thought to contribute to its pathogenesis  . In Dubois’ Lupus Erythematosus. Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus. Genomics 2000, 70:307–314. 88. Hogarth MB, Slingsby JH, Allen PJ, et a. Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice.

To date, three loci have been validated to confer susceptibility to inflammatory bowel disease . Lupus Erythematosus, Systemic/genetics.

To date, three loci have been validated to confer susceptibility to inflammatory bowel disease (IBD): the CARD15/NOD2 gene, the discs large homolog 5 gene (DLG5), and the IBD5 locus on 5q31 (IBD5). We have explored the possibility that these loci may also be associated with susceptibility to two other chronic inflammatory diseases, multiple sclerosis (MS) and systemic lupus erythematosus (SLE). Membrane Proteins/genetics. Multiple Sclerosis/genetics.

Susceptibility to systemic lupus erythematosus in the NZM2410 murine model maps to Sle1, Sle2, Sle3, and the H2 loci. Genetic dissection of human systemic lupus erythematosus (SLE) has been under intense studies during the past decade. To unravel how these loci contribute to the pathogenesis of lupus, individual NZM2410-derived genomic intervals bearing these loci have been successfully backcrossed onto the resistant C57BL/6 (B6) background. The focus of this study was to understand how Sle2 on murine chromosome 4 impacts the immune system.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by complex immunological .

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by complex immunological pathogenesis and diverse clinical features, as a consequence of multi-system inflammation. We have made remarkable progress in understanding the genetics of SLE over the last five years, including five published whole genome association analyses. We are now able to highlight, with confidence, at least 25 genetic loci that influence disease susceptibility. The primary motivation for performing these studies has been the identification of biological pathways involved in disease pathogenesis.

A susceptibility locus for human systemic have many hypotheses to test . Lupus susceptibility loci in New Zealand mice.

A susceptibility locus for human systemic have many hypotheses to test; the whole genome scan geno- lupus erythematosus (hSLE1) on chromosome 2q. J Autoimmun 2000; 14:169e78. typing is just the beginning. Magnusson V, Lindqvist AK, Castillejo-Lopez C, Kristjansdottir H, Steinsson K, Grondal G, et al. Genomics 2000; References 70:307e14. Chokkalingam AP, Alexander HC, et al.

The etiology of systemic lupus erythematosus (SLE) is determined in part by genetic factors which influence susceptibility to the disease

The etiology of systemic lupus erythematosus (SLE) is determined in part by genetic factors which influence susceptibility to the disease. These observations are based on advances in the analysis of human SLE and the increased knowledge provided b. ONTINUE READING.