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eBook The clinical features of sickle cell disease (Clinical studies) download
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Author: Graham R Serjeant
ISBN: 0444105921
Pages 357 pages
Publisher distributors for the U.S.A. and Canada, American Elsevier Pub. Co (1974)
Language English
Category: No category
Rating: 4.9
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ePUB size: 1373 kb
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eBook The clinical features of sickle cell disease (Clinical studies) download

by Graham R Serjeant


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Start by marking The Clinical Features Of Sickle Cell Disease as Want to Read: Want to Read savin. ant to Read. The Clinical Features. by Graham R. Serjeant. The Clinical Features Of Sickle Cell Disease. by. Graham R.

He is author or co-author of three books and over 140 publications on sickle-cell disease

Sickle cell disease was one of the first diseases to be explained at the molecular level

Sickle cell disease was one of the first diseases to be explained at the molecular level. Sickle cell disease was one of the first diseases to be explained at the molecular level

Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful .

Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year. Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect. The beneficial effects of hydroxyurea do not become manifest for several months, and its use must be carefully monitored. whilst in Sickle cell disease, the HbS is inherited along with another abnormal haemoglobin eg HbE, HbC, etc. Aims and objectives: This study was aimed at assessing the awareness and knowledge of sickle cell disease among students in a tertiary institution, as well as their attitude to the disease.

Clinical studies ;, v. 4. Classifications.

The clinical features of sickle cell disease Close. 1 2 3 4 5. Want to Read. Are you sure you want to remove The clinical features of sickle cell disease from your list? The clinical features of sickle cell disease. Published 1974 by North-Holland Pub. C. distributors for the . Clinical studies ;, v. S5 S46. The Physical Object. xxvi, 357 p. : Number of pages.

Identical or monozygotic twins occur in . % – . % of births, but to be useful for studies of hematology and clinical features, both twins must survive long enough to provide adequate data.

Sickle cell disease (SCD) refers to any one of the syndromes in which the sickle mutation is co-inherited with a mutation at. .The clinical manifestations of SCD are protean

Sickle cell disease (SCD) refers to any one of the syndromes in which the sickle mutation is co-inherited with a mutation at the other beta globin allele that reduces or abolishes normal beta globin production. These include sickle cell anemia (homozygous sickle mutation), sickle beta thalassemia, hemoglobin SC disease, and others. The clinical manifestations of SCD are protean. The major features are related to hemolytic anemia and vaso-occlusion, which can lead to acute and chronic pain and tissue ischemia or infarction.

The deficiencies in our current knowledge about the spectrum of the clinical course of patients with these conditions is discussed. The interaction of alpha thalassemia with sickle cell anemia and its possible effect upon the severity of the disease is summarized

in a cohort study of sickle cell disease

in a cohort study of sickle cell disease. Discrete gallstones later developed in 12 patients, but no stones developed in five patients; one patient with biliary sludge had no change in his condition for 5 years. cholecystectomy was indicated for biliary sludge.

Table I: Differential diagnosis of major genotypes of sickle cell disease. Clinical features Acute anaemia An acute life-threatening anaemia may occur with acute splenic sequestration and aplastic crisis

Table I: Differential diagnosis of major genotypes of sickle cell disease. Sickle test Electrophoresis Alkali Agar. Clinical features Acute anaemia An acute life-threatening anaemia may occur with acute splenic sequestration and aplastic crisis. Acute splenic sequestration usually occurs bet-ween 4 months and 5 years of age. In the Jamaican Cohort Study, it affected 30% of SS children by 5 years, and is a common cause of death. Its aetiology is unknown, but splenic enlargement traps circulating red cells causing the haemoglo-bin to fall by 2-6 g/dl within periods as short as 3 hours.